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B. Pignon

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Review Open access Sep 2026

Dynamical system modeling in schizophrenia: a narrative review of computational psychiatry frameworks

Abstract The temporal evolution of schizophrenia symptoms is inherently complex and non-linear. Clinical states fluctuate between relatively stable and highly disorganised phases. These dynamics are only partially captured by conventional diagnostic frameworks. This limitation has motivated the development of models th...

Héléne Soydemir, Christophe Gauld, M. Desroches et al. · 0 citations
Open access Aug 2026

Genetic architecture of treatment-resistant schizophrenia across East Asian and European cohorts: insights from GWAS, TWAS, and synaptic pathway analyses

There is promise in pathway-level and multi-omics approaches to elucidate biologically meaningful heterogeneity within SSD and support for synaptic mechanisms as potential targets for understanding and stratifying treatment-resistance is provided.

P. B. Leung, K. C. Wong, S. Smart et al. · 0 citations
Jul 2026

IQ and subclinical psychosis: The role of psychosocial stressors and core schemata.

BACKGROUND AND HYPOTHESIS Previous research in both clinical and non-clinical populations has suggested an association between intelligence quotient (IQ) and psychosis. The social defeat hypothesis posits that low status and repeated humiliation increase the risk of psychosis. The present study investigated the relatio...

Veronica Sandroni, A. Szöke, H. Peyre et al. · 0 citations

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