B. Polegato

Exogenous ketosis fails to mitigate cardiac dysfunction, mitochondrial and inflammatory dysregulation in acute doxorubicin-induced cardiotoxicity

Doxorubicin (DOX)-induced cardiotoxicity is driven by mitochondrial dysfunction, oxidative stress and inflammatory activation. In pathological conditions, the heart undergoes metabolic remodelling, increasing its reliance on ketone bodies (KB) as an auxiliary energy substrate. Although exogenous KB have demonstra...