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Author

B. Pradines

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Open access Sep 2026

Novel enantiopure pyridine-based aminoalcohols as promising antimalarial candidates.

Three new series of pyridine-based amino alcohols including twenty compounds were designed and synthesized using a short and optimized asymmetric synthetic route, and compound 10a was identified as the most promising candidate for malaria treatment.

A. Herrero, C. Tisnerat, Guillaume Bentzinger et al. · 1 citation
Open access Jul 2026

4-Aminoquinoline derivatives and benzoxaborole-4-aminoquinoline hybrids: synthesis, antiplasmodial evaluation, heme-inhibition and in silico studies

UV-visible spectroscopic titrations demonstrated that compound 8b binds monomeric heme more selectively than CQ at both physiological and digestive vacuole pH, supporting inhibition of hemozoin formation as its primary mode of action.

Anuradha Saini, Sumit Kumar, B. Pradines et al. · 0 citations

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