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Author

B. Prosser

2 papers indexed here

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Open access Aug 2026

Cardiac microtubules mediate transverse (t)-tubule growth and homeostasis

Transverse (t)-tubules enable rapid, synchronous Ca release required for efficient cardiac contraction by bringing L-type Ca channels into close apposition with ryanodine receptors. In heart failure with reduced ejection fraction (HFrEF), t-tubule disorganisation and loss occur alongside cardiac microtubule remodelling...

A. S. Whitley, G. W. P. Madders, A. Livesey et al. · 0 citations
Aug 2026

Single-Molecule Imaging Reveals ERK-Dependent Spatial Translation in Cardiomyocytes.

BACKGROUND Translational control of gene expression is crucial in cardiomyocytes, particularly in response to hypertrophic stimuli. The ERK (extracellular signal-regulated kinase) pathway plays a key role in inducing cardiac hypertrophy and regulating specific protein translation. However, it remains unclear how this s...

Itai Erlich, Guy Douvdevany, Rami Haddad et al. · 0 citations

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