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Metabolic dysfunction-associated steatohepatitis (MASH) represents a major global health burden, bridging isolated steatosis, progressive fibrosis and hepatocellular carcinoma. Recent paradigms highlight ferroptosis, an iron-dependent, lipid-peroxidation-driven form of regulated cell death, as a primary lytic initiatin...
The present review elaborated on the mechanisms by which PCSK9 contributes to several hallmarks of cancer, including sustained proliferative signaling, invasion and metastasis, metabolic reprogramming, angiogenesis and tumor immune evasion through the modulation of specific substrates.
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