Open access
Jul 2026
Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans
Genetic variants that increase the risk for complex diseases persist in human populations, despite adverse effects on health and longevity. Life-history theory predicts that such alleles can be maintained by trade-offs arising from pleiotropy, yet direct genomic evidence has been limited. We asked whether disease-assoc...
Eva Brigos-Barril, Claudia Vasallo, X. Farré et al.
· Nature Ecology & Evolution · 0 citations