285. Pharmacological NKCC1 inhibition prevents intergenerational microbiome and neurobehavioral abnormalities following maternal preconception TBI
Abstract Background Long-term consequences of traumatic brain injury (TBI) include dysregulated stress and inflammatory signaling and neurocognitive decline. Epidemiological evidence indicates increased psychiatric vulnerability in the offspring of parents with TBI, with greater abnormalities in sons. The mechanisms in...