Metabolites are generally viewed as substrates, products, cofactors, or regulators of individual proteins, whereas metabolites recurring across many protein families are often regarded as promiscuous binders. Here, we analyzed 989,058 BioLiP2 protein–ligand binding sites and assigned 929,546 sites to ECOD v295 homologo...
A global metabolite-mediated architecture with the capacity to coordinate proteins across otherwise distinct cellular systems is revealed and experimentally established metabolite-dependent complexes validate the local mechanism independently of LIGMAP.
This review explores the outstanding questions and challenges in developing covalent inhibitors beyond cysteine, highlighting current warhead chemistries, strategies for achieving selectivity, proteomic mapping advances, assessment of the intrinsic reactivity of the electrophiles targeting non-cysteine residues and opp...
B. Srinivasan, John B Taylor· British Journal of Pharmacol...· 1 citation
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