Second near-infrared (NIR-II; 1000 to 1700 nanometers) aggregation-induced emission luminogens (AIEgens) hold great promise for imaging-guided precision tumor phototherapy yet are limited by the intrinsic trade-off between fluorescence brightness and photothermal performance. Existing design strategies often yield comp...
Huan-Long Zheng, Tian-Tian Li, Tong Sun et al.· Science Advances· 0 citations
Point‐of‐care (POC) diagnostics play a critical role in early‐stage screening, disease monitoring, and therapeutic evaluation. However, their clinical translation remains limited by inadequate sensitivity, operational complexity, and dependence on bulky instrumentation. Aggregation‐induced emission luminogens, which...
Dan-Ni Hu, Yu-Bing Hu, Dong Wang et al.· FlexMat· 0 citations
Drug-resistant bacterial infections and persistent biofilm formation pose critical bottlenecks for diabetic wound management. To overcome these challenges, a sunlight (SL)-triggered aggregation-induced emission (AIE) photosensitizer, designated as MTP, was engineered and incorporated into an injectable thermosensitiv...
Da-Lu Xie, Xue-Ke Yan, Chen Cui et al.· ACS Nano· 0 citations
“One‑for‑all” phototheranostics has emerged as a promising alternative to conventional cancer therapies. Aggregation‑induced emission luminogens (AIEgens) are exemplary templates for constructing such versatile systems. However, developing robust NIR‑II (1000–1700 nm)‐emitting “one‑for‑all” phototheranostic AIEgens rem...
Miao-Miao Kang, Yu Pei, Zeng-Ming Yang et al.· Aggregate· 1 citation
Purely organic luminescent materials are pivotal for optoelectronics, with chalcogen-fused phenazines serving as basic building blocks owing to their strong electron donating ability and enhanced spin-orbit coupling effect. However, a systematic understanding of how the chalcogen identity governs intrinsic conformation...
Ting-Wei Ren, Jia-Xin He, Zhen-Jiang Liu et al.· Angewandte Chemie· 0 citations
Photocatalytic therapy (PCT) has emerged as an expanded framework for light-driven biomedicine. Specifically, photodynamic therapy (PDT) can be regarded as a classical oxygen-sensitized subtype, while broader photocatalytic pathways, including photoredox transformations, intracellular polymerization, and photocatalytic...
Traditional cancer treatment methods, such as chemotherapy, radiotherapy, and immunotherapy, are often limited by poor treatment efficacy, poor targeting, and adverse side effects, as well as intrinsic or acquired drug resistance, which are mainly caused by the complex and immunosuppressive tumor microenvironment. The...
Immunotherapy has created new opportunities for treating triple‐negative breast cancer (TNBC), but its benefit is often limited by an immunosuppressive tumor microenvironment. Here, we report BMFL, a folate receptor‐targeted liposomal nanoplatform that co‐delivers a near‐infrared aggregation‐induced emission luminogens...
Wen-Kai Zhang, Xue-Ke Yan, Xiepeng Deng et al.· Aggregate· 0 citations
This study addresses triple-negative breast cancer treatment by developing a photosensitizer, DBC, with a multiple-twist molecular architecture, offering broader readers an impactful paradigm for engineering multi-functional biomaterials to combat aggressive cancers.
It is demonstrated that the integration of natural bioactivity with supramolecular engineering provides a biocompatible strategy for coordinated tumor-bacterial disruption and immunogenic remodeling of the F. nucleatum-associated tumor niche in CRC.
Maliang Tao, Bin-Bin Wei, Yen-Yu Yang et al.· Advances in Materials· 0 citations
This study overcomes the intrinsic trade-off between radiative and non-radiative decay pathways in aggregation-induced emission luminogens (AIEgens) for phototheranostic applications and enables effective imaging-guided eradication of MRSA in back and joint abscess models.
Qi-Cheng Zhang, Jian Zhang, Lei Ye et al.· Acta Biomaterialia· 0 citations
Both in vitro and in vivo experiments demonstrate that DPP‐CE allows high‐contrast fluorescence imaging of tumors and effectively inhibits tumor growth under both normoxic and hypoxic conditions, while showing good biosafety.
Xuemei Dong, Lingan Zeng, Yunlong Liu et al.· Advanced Healthcare Material...· 2 citations
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