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Open access Sep 2026

Integrated murine and human transcriptomics prioritizes a multicellular mitochondrial signature associated with immune and parenchymal features in NAFLD/MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD), historically termed nonalcoholic fatty liver disease (NAFLD), involves metabolic dysregulation, mitochondrial stress, and immune remodeling. However, disease-associated multicellular transcriptional programs and their spatial context remain incompletel...

Lu-Lu Tang, Guang-Yan Luo, Li Zhang et al. · 0 citations
Review Open access Sep 2026

The Role of Mitochondrial Dysfunction in Hepatocellular Carcinoma: From Pathogenesis and Drug Resistance to Targeted Therapeutic Strategies

Abstract Hepatocellular carcinoma (HCC) is characterized by high malignancy and widespread drug resistance at advanced stages, posing formidable challenges in clinical diagnosis and treatment. Mitochondrial dysfunction is a core driver of HCC initiation and drug resistance. However, how its plasticity dynamically regul...

Si-Yu Zhao, Qian Liu, Jing Li et al. · 0 citations

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