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Author

Bagher Larijani

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Oct 2026

New hybrid molecules with 2,3,4,9-tetrahydro-1H-carbazol-1,3,4-oxadiazole-N-phenylacetamide framework as potent cholinesterase inhibitors.

AIMS In this study, new 2,3,4,9-tetrahydro-1H-carbazol-1,3,4-oxadiazole-N-phenylacetamide hybrids 8a-n as potential dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for the treatment of Alzheimer's disease (AD) were introduced. METHODS The target compounds were designed using a molecula...

Reza Hassanzadeh Dostkoh, Navid Dastyafteh, Aida Iraji et al. · 0 citations
Open access Aug 2026

Novel diazene-tri(phenoxy-1,2,3-triazole-acetamide) derivatives as potent α-glucosidase inhibitors: synthesis, biological evaluation, and in silico studies

Kinetic enzyme assays revealed that compound 9f acts as a competitive inhibitor of α-glucosidase, competing with the natural substrate for binding to the active site, with a Ki value of 100 nM, and pharmacokinetic predictions showed that compound 9f exhibits a bioavailability radar and drug-likeness profile similar to...

Shahab Kermaninia, M. Sayahi, Mohammad Halimi et al. · 0 citations

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