An Evidence-Based Biomarker Framework for n-Hexane-Induced Neuropathy: Urinary 2,5-Hexanedione, Pyrrole Adducts, and Neurofilament Light Chain.
Neuropathy induced by n-hexane is a classical toxic axonopathy caused primarily by metabolic activation of n-hexane to 2,5-hexanedione (2,5-HD). Although urinary 2,5-HD is widely used for biological monitoring, its interpretation remains complicated by analytical heterogeneity, particularly the distinction between free...