Author

Baisheng Lai

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#artificial intelligence Preprint Sep 2026

PopPert: Population-level Joint-Distribution Modeling for Single-Cell Perturbation Prediction

PopPert predicts perturbation-induced changes in distribution parameters, eliminating the need for cell-level correspondence and reducing sensitivity to single-cell noise, establishing population-level joint distribution learning as an effective paradigm for predicting transcriptional responses from unpaired single-cel...

Han-Dong Wang, Jiaxin Qi, Hao-Chen Feng et al. · 0 citations

#artificial intelligence Preprint Sep 2026

SymFold: Synergizing Evolutionary and Structural Priors for Accurate Protein Inverse Folding

This work introduces a symmetric dual-path architecture that both leverages PLMs for pretrained sequence evolution knowledge and MPLMs for pretrained structural knowledge to iteratively guide protein sequence generation.

Han-Dong Wang, Jiaxin Qi, Baisheng Lai et al. · 0 citations