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Neurotensin receptor agonist PD149163 modulates LPS-induced sub-acute gut inflammation by inhibiting TLR4/NF-κB/NLRP3 inflammasome pathway: In vivo, in silico and network pharmacology analyses.
Bacterial lipopolysaccharide (LPS)-induced sub-acute gut inflammation and barrier impairment contribute to several gastrointestinal tract (GIT) disorders, including inflammatory bowel disease, celiac disease, and sepsis. The present study elucidates the efficacy of neurotensin receptor 1 (NTSR1) agonist against LPS-ind...