Serine/threonine kinase 33 (STK33) is a male germ-specific nonhormonal contraceptive target that is both genetically and chemically validated. Building on our previously reported reversible male contraceptive inhibitor, CDD-2807, we conducted systematic structure−activity relationship (SAR) and structure−property rel...
A. Ku, H. Ta, Yong Wang et al.· Journal of Medicinal Chemist...· 0 citations
Noncanonical redox cofactors (NRCs) are low-cost alternatives to the natural redox cofactors nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) for biomanufacturing, offering exquisite electron-delivery control, yet their adoption is limited by the scarcity of compatible en...
Samer Saleh, Ning-Hsiang Hsu, Emma Luu et al.· Nature Chemical Biology· 0 citations
Results support a model in which conserved hydrophobic active-site residues optimize the geometric and electrostatic environment required for efficient carbapenem deacylation and turnover, and provide mechanistic insight into OXA-48 catalysis that may be exploited to design inhibitors targeting the enzyme.
DorisMia Taylor, D. Ngango, Jia-Yi Fan et al.· ACS Infectious Diseases· 0 citations
Three-dimensional protein crystals are ordered, porous macroscopic materials with potential applications in catalysis, biosensing, and biomedicine. However, most protein crystals are obtained by empirical screening, providing limited control over the lattice architecture, pore geometry or component composition that det...
Zhe Li, Shun-Zhi Wang, W. Sheffler et al.· bioRxiv· 0 citations
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