Open access
Sep 2026
Structural basis for differential inhibition of THIK1 by chemically related inhibitors
TWIK-related halothane-inhibited potassium channel 1 (THIK1) is a two-pore domain potassium (K2P) channel highly expressed in microglia that contributes to microglial homeostasis and neuroinflammatory responses. Pharmacological inhibition of THIK1 suppresses tonic K+ currents and attenuates NLRP3-dependent IL-1β releas...
Ran Zhang, Xiang-Yu Fang, Rui-Heng Zhang et al.
· bioRxiv · 0 citations