Chronic inflammation can remodel the prostatic tissue ecosystem and may increase susceptibility to prostate cancer (PCa); however, direct causal evidence linking chronic prostatitis (CP) to PCa is still lacking, and the mechanisms of sustained intercellular information transfer remain unclear. Exosomal miRNAs are stabl...
Yi-Hang Shen, Bao-Jun Ju· Frontiers in Immunology· 0 citations
The proposed MSK1-dependent amplification loop is a testable hypothesis rather than a demonstrated CP/CPPS mechanism, and patient-tissue phosphoproteomics, cell-resolved transcriptomics and ATAC-seq, and phenotype-stratified intervention studies are needed before therapeutic claims can be made.
Yi-Hang Shen, Bao-Jun Ju· Frontiers in Immunology· 0 citations
Prostate cancer bone metastasis is increasingly understood as a dynamic interaction between disseminated tumor cells and a bone microenvironment that can be remodeled before, during, and after tumor-cell arrival. Extracellular vesicles (EVs), including preparations described as exosomes, may contribute to this commun...
Yi-Hang Shen, Bao-Jun Ju· Frontiers in Cell and Develo...· 0 citations
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