Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder and progresses through distinct pathological stages whose specific drivers remain unclear. Here we show that cytosolic prostaglandin E synthase (cPGES) drives MASLD progression in a cell-type-specific, prostagl...
Dan-Dan Zhong, Ranran Qiao, Guo-Gui Quan et al.· Cell Reports· 0 citations
Ganoderic acids (GA), a class of specific triterpenoids found exclusively in Ganoderma lucidum, have broad pharmacological activities. The purpose of this study was to determine whether GA attenuates dexamethasone (DEX)-induced muscle atrophy and to explore the underlying mechanisms. The therapeutic effect of GA (at in...
Ke-Cheng Tang, Yan Yu, Yi-Ru Chen et al.· Phytotherapy Research· 0 citations
ABSTRACT Natural products, including isolated compounds, complex extracts, traditional medicinal preparations and marine, microbial, fungal and animal‐derived materials, remain important sources of therapeutic agents and pharmacological discovery. However, variation in biological source materials, preparation methods,...
P. Tveden-Nyborg, Bao-Xue Yang, Gökay Albayrak et al.· Basic & Clinical Pharmacolog...· 0 citations
It is demonstrated that Nrf2 deficiency exacerbates AKI-CKD progression through redox imbalance and ferroptosis-mediated maladaptive repair, and targeting Keap1-Nrf2 with 6K protects against renal injury and fibrosis, highlighting its therapeutic potential for kidney diseases.
Yi-Ming Wang, Yi Sun, Ting Zhou et al.· Redox Biology· 0 citations
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