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Review Open access Aug 2026

The mechano-immunological barrier in fibrosis-associated lung cancer: targeting matrix stiffness and the Piezo1 axis for microenvironment normalization

While mechanotransduction influences various lung cancer subtypes, this review focuses specifically on fibrosis-associated non-small cell lung cancer (NSCLC), where the progression from pulmonary fibrosis to malignancy is mediated by aberrant mechanotransduction. Progressive extracellular matrix (ECM) stiffening (8–25...

Linfeng Guo, Jia Wang, Bao-Yi Ni et al. · 1 citation · ⚡1
Review Open access Sep 2026

Cancer cachexia as an immunometabolic syndrome: targeting the immunometabolic interface with traditional Chinese Medicine monomers and formulas

Cancer cachexia is conventionally viewed as muscle wasting but is increasingly recognized as a tumor-driven immunometabolic syndrome. This systemic disorder is characterized by a vicious cycle of metabolic dysregulation, systemic inflammation, and immune evasion, severely compromising the efficacy of immune checkpoint...

Bao-Yi Ni, Shu-Hang Wang, Xi Zhang et al. · 0 citations

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