Author

Barbara Smolak

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Conference Open access Sep 2026

Metabolic and Signaling Pathways Affected by Photodynamic Therapy (PDT) with Protoporphyrin IX

Protoporphyrin IX (PpIX) occupies a unique nexus in photodynamic therapy (PDT) by bridging the endogenous metabolism of heme biosynthesis with highly efficient, light-induced cytotoxicity. Administered via its precursor 5-aminolevulinic acid (5-ALA) or its derivatives, intracellularly generated PpIX undergoes intersyst...

R. Marunych, D. Bartusik-Aebisher, Klaudia Dynarowicz et al. · Micro · 0 citations

#graph neural networks Review Open access Oct 2026

Artificial Intelligence in Photodynamic Therapy: From Molecular Design of Photosensitizers to Intelligent Delivery, Adaptive Dosimetry, and Personalized Prognostication of Results

Photodynamic therapy (PDT) is a minimally invasive therapeutic approach based on the light-induced activation of a photosensitizer in the presence of molecular oxygen, resulting in the generation of reactive oxygen species, including singlet oxygen. Despite local selectivity and low systemic toxicity, reproducibility o...

R. Marunych, D. Bartusik-Aebisher, Klaudia Dynarowicz et al. · International Journal of Mol... · 0 citations

Review Open access Aug 2026

Photodynamic Therapy in Cancer: Mechanisms, Photosensitizer Technology, Vitamin Modulation, and Rational Combination Design

Overall, PDT combination design should be guided by whether adjunctive agents support or undermine photosensitizer accumulation, oxygen availability, ROS-mediated cytotoxicity, and immune activation, when selected according to mechanistic compatibility.

Ilaf Naser, D. Bartusik-Aebisher, Barbara Smolak et al. · Biomedicines · 1 citation