Open access
Sep 2026
Baseline cellular state shapes the molecular impact of mutant Kirsten rat sarcoma viral oncogene homologue (KRAS) alleles in reconstituted pancreatic cancer cells
This study establishes a comprehensive multi-omics resource for KRAS signalling in PDAC and demonstrates that cellular context exerts a stronger influence than allele identity in shaping molecular profiles, with implications for interpreting putative allele-specific signalling dependencies.
Yanixa Quiñones-Avilés, Barbora Šalovská, Cassandra S. Markham et al.
· Molecular Omics · 0 citations