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Bart Melgers

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Aug 2026

Distinct plasmid- and host-encoded mechanisms drive small plasmid copy number-mediated heteroresistance in Escherichia coli

This study investigates the contribution of small plasmids to heteroresistance using a clinical bloodstream Escherichia coli isolate carrying a 12 kb ColE1-type plasmid, and shows that this plasmid drives transient β-lactam heteroresistance through massive increases in plasmid copy number.

Angelika Ntokaki, E. Joffré, Bart Melgers et al. · 0 citations

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