Author

Bastian Schiffthaler

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Open access Aug 2026

Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes

It is shown that off-target editing and translocations vary widely between individual cells and organs, motivating the development of more sensitive and organ-specific safety assays for CRISPR therapies.

Alexandra Madsen, Niklas Selfjord, M. Martinez-Lage et al. · Nature Communications · 0 citations