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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Behdad Afzali

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Open access Jul 2026

A BACH2-STAT5 transcriptional module licenses a short intracellular C3 proteoform in activated CD4+ T cells 2308647

A BACH2—STAT5 transcriptional module is identified that is essential for C3 expression in activated CD4+ T cells and redirects C3 output toward a short, intracellular proteoform with noncanonical complement activity.

Jorge Trujillo, D. Chauss, Luopin Wang et al. · 0 citations
Open access Jul 2026

Inherited C5aR2 deficiency leads to uncontrolled inflammatory T cell responses and autoinflammatory disease 2309676

A previously unrecognized CPM-dependent mechanism that balances C5aR1 and C5aR2 signaling to limit pathological T cell activation is uncovered, revealing an intrinsic complement-driven checkpoint that constrains effector T cell immunity.

Erin E. West, Nicolas S. Merle, Ayden Case et al. · 0 citations

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