CD8
+
T cells play a crucial role in anti-tumor immunity; however, their functionality is compromised by exhaustion driven by chronic antigen exposure, poor tumor microenvironment, and metabolic dysfunction. Activated CD8
+
T cells undergo extensive proteomic remodeling, which includes the induction of the IRE1-X...
Keith A. Nair, Jessica Lee, Olivia Zaleski et al.· Frontiers in Immunology· 0 citations
E engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons are developed and validated their utility across biochemical, electrophysiological and behavioral studies of psychedelic mechanisms.
Yi-Ting Chiu, A. Y. Deutch, Wei Wang et al.· Nature Neuroscience· 0 citations
Findings indicate MCU-mediated acetyl-CoA metabolism as a critical anti-ferroptosis mechanism, which can be investigated as a potential therapeutic candidate for tumor treatment.
Jianwen Chen, Bao Zhao, Hong Dong et al.· Proceedings of the National...· 1 citation· ⚡1
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