BACKGROUND
Multiple system atrophy (MSA) is an adult-onset, fatal, neurodegenerative disease lacking mechanistic understanding, early diagnosis, and specific treatments. Metabolomics has been widely used in neurodegenerative diseases for biomarker identification and pathophysiology exploration; however its application...
Lin-Lin Wan, Zhao Chen, Na Wan et al.· Movement Disorders· 0 citations
This study suggests that polyG protein aggregates in NIID may shift the global RNA splicing profile toward an immature state, potentially through the sequestration of key splicing factors, such as SF3B4, thereby identifying new avenues for understanding the pathogenic mechanisms underlying NIID.
Jia-Xin Yang, You-Qi Zheng, Jian-Yi Hu et al.· Neuroscience Bulletin· 0 citations
BACKGROUND
Huntington's disease (HD) is a fatal neurodegenerative disorder lacking effective treatment. The relationship between modifiable factors and age at onset (AAO) in HD remains controversial and causally unconfirmed. Identifying causal modifiers of AAO is crucial for delaying onset and disease prevention.
MET...
Lin-Liu Peng, Zhao Chen, Lin-Lin Wan et al.· Current Neuropharmacology· 0 citations
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