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Review Open access Sep 2026

Boosting T cell antioxidant capacity: A strategic approach to overcome immunosuppression in solid tumors.

Adoptive T cell therapy faces significant hurdles in solid tumors due to the immunosuppressive tumor microenvironment (TME), wherein aberrant accumulation of reactive oxygen species (ROS) serves as a critical driver of therapeutic resistance. Conventional systemic antioxidant strategies are constrained by their non-sel...

Fan Liu, Yu-Xin Pang, Luo-Yang Wang et al. · 0 citations
Review Open access Sep 2026

Interleukin-35 and pancreatic cancer: research progress from tumor-promoting mechanisms to treatment resistance.

Interleukin-35 (IL-35) is an immunosuppressive cytokine whose expression levels are elevated in tumor tissues and serum of pancreatic cancer patients and are associated with disease prognosis. This article is a narrative review that summarizes the multiple tumor-promoting functions of IL-35 in pancreatic cancer and the...

Yuan-Zhen Guo, Jie Liang, Xiao-Li Liu et al. · 0 citations

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