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Ben A. Krinkel

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Jul 2026

Abstract B089: Targeting metabolic vulnerabilities in cancer through structure-guided discovery of novel malic enzyme inhibitors

These findings establish mitochondrial malic enzymes, particularly ME2/ME3, as tractable metabolic targets for cancer therapy, and provide a strong foundation for rational optimization of potency and isoform selectivity.

Ben A. Krinkel, Y. Yosaatmadja, M. Slayton et al. · 0 citations