Allosteric communication between distant sites in proteins is central to biological regulation and underlies the efficacy of many drugs. Allostery allows proteins to function as molecular switches, with their activities controlled by ligand binding, covalent modifications, and mutations outside their active sites. Allo...
Yu-Jing Ma, Qi-Le Jin, Ben Lehner et al.· bioRxiv· 0 citations
This pipeline identified 6 known and 43 novel CRBN-pomalidomide binders, including orthogonally validated hits that provide privileged starting points for MGD development, and expects this binding-focused workflow to be applicable to other MGD-E3 ligase systems, potentially extending the scope of this emerging drug cla...
Pius Galli, Shuhao Xiao, Y. Meng et al.· Nature Biotechnology· 1 citation
The activity and abundance of >160,000 variants are quantify the activity and abundance of >160,000 variants to construct complete maps of the energetic and allosteric architectures of five human kinase domains: SRC, FGR, JNK2/MAPK9, ZAK/MAP3K20, and TSSK2.
Carla Folgado, Antoni Beltran, Ben Lehner· bioRxiv· 0 citations
This study provides comprehensive quantitative maps of the sequence determinants of human programmed readthrough and suggests that three examples of programmed readthrough are located on distinct local fitness peaks, each defined by different upstream and downstream architectures built around a shared CUAG core motif.
Ignasi Toledano, Fran Supek, Ben Lehner· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
