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Open access Sep 2026

Toxicity of MAPT 4R RNA Contributes to Motor Neuron Degeneration in ALS

MAPT (Tau) dysregulation is implicated in several neurodegenerative diseases, but its contribution to amyotrophic lateral sclerosis (ALS) is poorly understood. Here we show that mRNA isoforms encoding 4-repeat (4R) Tau are upregulated and cytoplasmically enriched in iPSC-derived motor neurons (MNs) from VCP-mutant and...

H. Crerar, Michele Stasi, Koustav Pal et al. · 0 citations
Review Open access Aug 2026

Intron retention in health and amyotrophic lateral sclerosis

A role for IR is emerging in both health and neurodegenerative diseases, including amyotrophic lateral sclerosis, and its potential as a therapeutic target is highlighted, as well as how IRTs may influence subcellular localization of ribonucleoprotein complexes, loss of function of bound RNA binding proteins (RBPs) and...

Chloe Y Wang, Stephanie Taylor, Virenkumar A Pandya et al. · 0 citations

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