Author

Benjamin F. Cravatt

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Open access Oct 2026

Lipid acyl chain remodeling governs KRAS nanoclustering and oncogenic functions through membrane composition control

KRAS signaling is spatially organized within the dynamic proteolipid nanoclusters on the plasma membrane (PM) that selectively concentrate anionic phospholipids, yet the molecular determinants governing this lipid sorting remain incompletely defined. Here we identify phospholipid acyl chain composition as a critical re...

Neha Arora, Rafael Bravo, Hong Liang et al. · bioRxiv · 0 citations

Open access Aug 2026

Activity-based profiling of primary brain cells identifies covalent allosteric modulators of HCN channels

An activity-based protein profiling strategy for mapping the covalent ligandability of primary brain cells isolated from mice and identified stereoprobe ligands for diverse nervous system-enriched proteins, including chemical probes that modulate HCN channel function in cells.

Elva Ye, Alberto Russo, Roberta Castelli et al. · bioRxiv · 0 citations

Open access Jul 2026

ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing

ESAPE (Endogenous Site-specific Competition Assays using Prime Editors using Prime Editors), a platform for the site-resolved functional analysis of covalent ligands in cells, identifies multiple covalent ligand-protein interactions that impair cancer cell growth.

Jason Tse, William R. Brothers, Rachel E. Hayward et al. · bioRxiv · 0 citations