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Author

Benjamin Wolozin

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Open access Oct 2026

Progressive remodeling of global protein interaction networks in a mouse model of tauopathy.

Neurodegenerative disease is marked not just by loss of proteins or cells, but by dynamic rewiring of macromolecular interaction networks that precede and drive pathology. Here, we present a temporally resolved, systems-scale map of multi-protein complex remodeling in a tauopathy model, integrating co-fractionation mas...

Wei-Wei Lin, S. Phanse, S. V. D. van der Spek et al. · 0 citations
Review Open access Sep 2026

The Paradox of Tau and RNA-Binding Proteins: How Adaptive Stress Granule Regulation Becomes Pathological with Aging

Reducing biomolecular condensates in stress and disease could provide a general effective therapeutic approach for multiple neurodegenerative diseases, according to specific pathways being pursued for reducing levels of stress granules, aggregated RNA binding proteins and oligomeric Tau.

Benjamin Wolozin, Merci N. Best, Madhav Ellini et al. · 0 citations

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