Microglial Presenilin-1 modulates neuronal function and memory-associated behaviors.
Microglial cells, the macrophages of the brain parenchyma, are increasingly recognized to play a key role in synaptic plasticity and function. Presenilin 1 (PS1) is an essential protein involved in learning and memory; the loss of neuronal Presenilin function causes cognitive deficits and impaired synapse plasticity in...