Oncolytic viruses (OVs) combine tumour-selective infection and replication with direct tumour-cell destruction and the capacity to induce antitumour immune responses. This review critically synthesises the cellular mechanisms, engineering strategies, preclinical development, clinical translation, major limitations, a...
N. Ng, Rebecca Shin-Yee Wong, Bey Hing Goh· Clinical and Experimental Me...· 0 citations
Summary Background The drivers of mortality and their associated risk factors evolve throughout the course of life. Understanding these transitions is essential for effective, equitable, and age-appropriate health interventions. Methods As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 20...
Tai-Shun Li, P. Charalampous, S. C. C. van der Lubbe et al.· Lancet Public Health· 1 citation
Ovarian cancer (OC) remains difficult to detect at an early stage, and current screening approaches using CA125 and transvaginal ultrasonography have not demonstrated sufficient benefit for population screening. DNA methylation is a promising biomarker class because epigenetic alterations may arise early in tumourigene...
Jeremy Yuan-Sheng Leow, N. Ng, Rebecca Shin-Yee Wong et al.· Molecular Biology Reports· 0 citations
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