Open access
Aug 2026
Evolutionary divergence V-ATPase function in macropinocytic cup remodeling
This work uncovered an unprecedented role of V-ATPase in shaping the macropinocytic cup in the pathogenic amoeba Entamoeba histolytica and highlights the novel role of V-ATPase in directly driving actin polymerization, in conjunction with phosphatidic acid, to shape the macropinocytic cup.
Bhagyashree Chordiya, Navyaka Padavala, Amisha Sharma et al.
· bioRxiv · 0 citations