Bharath Kumar Jakkula

Explainable machine learning and hybrid transformer-based proteochemometric modelling for breast cancer molecular subtyping and multi-target natural product discovery

Breast cancer comprises five intrinsic molecular subtypes with distinct transcriptomic programs, prognoses, and therapeutic vulnerabilities. Yet, accurate subtype discrimination remains limited by boundary-overlap and poor cross-cohort generalisability, while single-target agents often fail against pathway redundancy...