Author

Bhavesh D. Patel

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Open access Sep 2026

Bioanalytical Method Development and Validation for a Novel Secretory Phospholipase A₂ Inhibitor by LC-MS/MS and its Application to a Pharmacokinetic Study in Mice

Objective: This study aimed to develop and validate a sensitive LC–MS/MS method for quantifying a novel Secretory phospholipase A₂ (sPLA₂) inhibitor, compound-7(L), in mouse plasma and to evaluate its application in pharmacokinetic studies. Methods: A bioanalytical LC–MS/MS method was developed and validated according...

Nageswararao Pulakundam, Bhavesh D. Patel, Naresh P. et al. · International Journal of App... · 0 citations

Open access Aug 2026

BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF COMPOUND-9(O) USING LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY AND ITS APPLICATION TO A PHARMACOKINETIC STUDY

The validated LC-MS/MS bioanalytical method showed excellent specificity and selectivity, with satisfactory linearity over the validated concentration range from 1.00 to 1000 ng/mL, and met the acceptance criteria as per ICH M10 guidelines, confirming the robustness of the method.

Nageswararao Pulakundam, Bhavesh D. Patel, M. Jangid et al. · Asian Journal of Pharmaceuti... · 0 citations