Circular RNAs (circRNAs) are endogenous, covalently closed RNA molecules generated through back-splicing that exhibit exceptional stability, evolutionary conservation, tissue-specific expression and diverse regulatory functions. Compared with conventional RNA-based therapeutic platforms, such as messenger RNAs (mRNAs),...
Niranjan Kumar, Chainsee Saini, Rashi Soni et al.· Frontiers in Pharmacology· 0 citations
An integrated view of MELK dysregulation in LUAD is provided, linking its G2/M-associated activity with post-transcriptional regulation, immune features, and potential therapeutic targeting.
Kritika Jangir, Niranjan Kumar, Chainsee Saini et al.· Frontiers in Oncology· 0 citations
Cells undergo tight regulation during the mitotic phase of the cell cycle, which produces genetically identical daughter cells and prevents the segregation of duplicate chromosomes. This regulatory network has identified maternal embryonic leucine zipper kinase (MELK) as a proliferation-associated regulator. MELK is hi...
Kritika Jangir, Prachi Patidar, Bhavika Baweja et al.· Frontiers in Oncology· 0 citations
This review consolidates current knowledge of TTK function beyond its canonical SAC activity, emphasizing its emerging roles in DNA damage response, epithelial-mesenchymal transition, and oncogenic signaling pathways.
Prachi Patidar, Kritika Jangir, Chainsee Saini et al.· Cell Communication and Signa...· 0 citations
A robust G2/M -associated regulatory framework in LUAD is defined, characterized by reciprocal dysregulation of oncogenes and tumor suppressors and associated with the predicted TMPO-AS1–hsa-let-7b-5p regulatory network, which is linked to a less immunosuppressive tumor microenvironment, offering potential prognostic a...
