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Author

Bi-Chao Zhang

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Oct 2026

PBK drives pulmonary fibrosis via activating p53/ACVR1C/Smad-mediated epithelial-mesenchymal transition.

Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited therapeutic options. PDZ-binding kinase (PBK), also known as T-cell-originated protein kinase activated by lymphokines (TOPK), is implicated in cancer progression and inflammation, yet its role in fibrosis remains unexplored. This...

T. Ruan, Yu Zhen, Bei-Lei Wang et al. · 0 citations

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