Author

Bi-Jun Wang

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Open access Sep 2026

ROS-responsive biomaterial delivery of the TCM-derived small molecule coptisine protects stem cells and attenuates intervertebral disc degeneration

Oxidative stress compromise nucleus pulposus-derived mesenchymal stem cells (NPMSCs) and restrict endogenous repair in intervertebral disc degeneration (IDD). Here, human nucleus pulposus (NP) tissues showed that secreted phosphoprotein 1 (SPP1) expression increased with degeneration severity. Screening of 2,987 trad...

Shou-Yun Xiao, Ning-Hang Ruan, Bi-Jun Wang et al. · Frontiers in Bioengineering... · 0 citations

Open access Aug 2026

TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7‐driven ENO1 deubiquitination during intervertebral disc degeneration

Abstract Background The pathology of intervertebral disc degeneration (IDD) is characterized by metabolic dysregulation within nucleus pulposus (NP) cells. TRIM25 has been implicated in diverse tumors and pathological processes, yet its precise role in mediating mitochondrial function and metabolic alterations during I...

Xiao-Ming Liu, Wen-Yu Zhang, Hang Feng et al. · Clinical and Translational M... · 0 citations