Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces
Natural killer (NK) cells eliminate target cells through antibody-dependent cell-mediated cytotoxicity (ADCC), initiated by CD16a (FcγRIIIa) recognizing the Fc region of antibodies bound to the target cell surface. While the recognition is considered to be driven by CD16a-Fc binding avidity, it fails to explain why Fc...