Author

Biao-Qing Lu

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Review Open access Aug 2026

Myeloid-derived suppressor cells in laryngeal squamous cell carcinoma: an underexplored immunosuppressive axis and strategic target for overcoming checkpoint inhibitor resistance

Laryngeal squamous cell carcinoma (LSCC) shows a persistently low objective response rate to immune checkpoint inhibitors (ICIs) targeting the programmed death-1 (PD-1) pathway. Its immunosuppressive tumor microenvironment (TME), enriched in tumor-associated macrophages, immunosuppressive tumor-associated neutrophils (...

Guan-Jiang Huang, Xue-Sen Yang, Peijie Li et al. · Frontiers in Immunology · 1 citation

Review Open access Aug 2026

Cancer-associated fibroblasts and immune remodeling in laryngeal squamous cell carcinoma: evidence and translational perspectives

Laryngeal squamous cell carcinoma (LSCC) remains a clinically challenging malignancy of the head and neck. Because organ preservation is a major therapeutic objective in LSCC, stromal biology is of particular clinical relevance. Stromal factors influence local disease control, functional outcomes, and treatment resista...

Wei-Zhe Hong, Guan-Jiang Huang, Qing Luo et al. · Frontiers in Immunology · 1 citation