Aug 2026
Thermal Stabilization of Ubiquitin in Hydrophobic Amino Acid Solutions via Coupled Modulation of Solvation Structure and Dynamics.
It is demonstrated that hydrophobic amino acids enhance protein thermal stability through a coupled modulation of solvation structure, solvent dynamics, and hydrogen-bonding interactions, with distinct mechanisms depending on side-chain size and aggregation propensity.
Rabiul Gazi, Bilash Maity, Madhurima Jana
· Journal of Physical Chemistr... · 0 citations