Metabolic alterations are increasingly recognized during influenza virus infection, but how local lactate accumulation shapes antiviral immunity remains poorly characterized. By integrating time-series targeted energy metabolomics, single-cell RNA sequencing, flow cytometry, and functional perturbation, we show that in...
C. Lyu, Jiu-Yang Xu, Yu-Lin Zhang et al.· Cell Reports· 0 citations
ABSTRACT Influenza A virus (IAV) infection remains a persistent global health challenge with limited antiviral drugs. Viral entry represents a potential multifaceted target for antiviral intervention; however, there is a limited number of approved inhibitors that effectively prevent IAV entry. Here, we identify the rec...
Wen-Ting Zuo, Di He, Dong-Hong Wang et al.· Emerging Microbes and Infect...· 0 citations
Numerous single-cell RNA sequencing (scRNA-seq) studies have been conducted in the field of COVID-19 immunology, with a predominant focus on peripheral blood mononuclear cells (PBMCs). In contrast, longitudinal investigations of the pulmonary microenvironment have posed substantial clinical and technical challenges. He...
