Divergent Evolutionary Trajectories of Pseudomonas aeruginosa PAO1 under Trace versus Preservative-Level Antimicrobial Methylisothiazolinone Exposure.
Isothiazolinones are widely used nonantibiotic antimicrobials with high electrophilic reactivity toward bacterial protein thiols. Although this reactivity leads to rapid degradation and low environmental persistence, their potential to drive cryptic microbial evolution remains poorly understood. Here, we focused on met...