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Open access Oct 2026

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

ABSTRACT The early‐stage hippocampal development depends on precise synaptic remodeling, processes where microglia play indispensable roles. Disruption of this event reshape hippocampal neural circuit architecture and heighten the risk for long‐term memory, learning, and behavioral deficits. Manganese (Mn), a widesprea...

Ke-Yu Chen, Bin He, Kuan Liu et al. · 0 citations

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