Author

Bin Liu

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Open access Sep 2026

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

ABSTRACT In adult mammals, poor functional recovery after spinal cord injury (SCI) is largely due to the very limited capacity to reconstruct damaged neural connections together with neuronal loss. Here, we identify the neuroprotective role of Zdhhc17 as a palmitoyl acyltransferase (PAT) following SCI. Neuron‑specific...

Mei-Xuan Chen, Huan Chen, Si-Ning Ding et al. · Advancement of science · 0 citations

Review Sep 2026

Single-cell and Spatial Omics Reveal Spinal Cord Injury Microenvironmental Heterogeneity Relevant to Neural Interfaces and Spinal Neuromodulation.

OBJECTIVE Spinal cord injury (SCI) interrupts brain-spinal communication and causes persistent motor, sensory, and autonomic deficits. MATERIALS AND METHODS We summarize the current clinical and translational evidence on brain-computer interface (BCI)/epidural electrical stimulation (EES)/brain-spinal interface (BSI)...

Ming-Jie Lu, Jia-Wei Di, Ming-Zhu Deng et al. · Neuromodulation (Malden, Mas... · 0 citations

Jul 2026

PLIN2-PGAM5-regulated lipid droplet-mitochondria contacts drive microglial neuroinflammation after spinal cord injury via fatty acid metabolic reprogramming.

The findings identify the PLIN2-PGAM5 as a critical metabolic-immune pathway and suggest that targeting organelle-contact-mediated metabolic reprogramming represents a potential therapeutic strategy for CNS injury.

Daoqiang Huang, Hong Li, Yiqian Luo et al. · Cell Death and Differentiati... · 2 citations