Author

Bin Shao

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#artificial intelligence Preprint Sep 2026

ZGCM-1: A Fully Open and Extremely Efficient Foundation Model for Math and Agentic Search

In this work, we present ZGCM-1, a fully open 7B dense foundation model trained from scratch with extreme data, system, and algorithmic efficiency. ZGCM-1 is founded on a core premise: compact models cannot passively memorize the open web, but can overcome parametric capacity limits by coupling deliberate internal thin...

Ji-Yan He, Guang Liang, Hao Liu et al. · 0 citations

Open access Aug 2026

Chimeric Induced Cooperativity Opens the Design Space of Eukaryotic Gene Regulation

Predictive engineering of eukaryotic transcription is limited by the coupling of signal sensing, DNA binding, TF abundance and promoter output. Here we establish chimeric induced cooperativity (CIC), a modular architecture that separates LBD, DBD and AD functions and links them to promoters with tunable basal and maxim...

Yi-Yan Zhan, Zeng-Li Li, Xin-Rui Li et al. · bioRxiv · 0 citations