Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation.
Polyketides constitute a major class of natural products with remarkable structural diversity and biological activities. While bacteria predominantly produce polyketides via modular type I polyketide synthases (PKSs), eukaryotic modular PKSs remain largely unexplored. Here, we report the functional characterization of...