Cucurbitacin B suppresses GBM progression by inducing GADD45α-Dependent PCNA downregulation and DNA replication arrest
Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by uncontrolled proliferation and resistance to current standard chemoradiotherapy. Natural products have emerged as promising anticancer agents, yet the therapeutic mechanisms of Cucurbitacin B (CuB), a highly bioactive triterpenoid, in G...